Advances in Experimental Medicine and Biology
Advances in Experimental Medicine and Biology
1. Historical Aspects of Xeroderma Pigmentosum and Nucleotide Excision Repair. 2. Clinical Features of Xeroderma Pigmentosum. 3. Xeroderma Pigmentosum and Skin Cancer. 4. XPA Gene, Its Product and Biological Roles.
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To understand the molecular mechanisms of XP, XP mouse models have been used, and mice deficient in XPA, XPC, XPD, XPG, XPF, and XPA/CSB have been produced and analysed. This title includes a chapter that analyzes the world distribution of XP and shows that Japan has the highest incidence of XP and of varying complementation groups.