Emerging from the International Conference on Optimization, Modeling, Simulation, and Analytics (Hanoi, Vietnam, August 15-16, 2025), this volume brings together selected studies that explore various aspects of optimization, simulation, modeling, and analytics. The contributions cover a wide spectrum of domains, including industrial engineering, supply chain management, healthcare, finance, and other related fields. The book provides a comprehensive analysis of contemporary operational challenges and state-of-the-art approaches developed to address them. The topics encompass techniques and applications in operations management, e-commerce, security, healthcare matching, and hospitality, among others. By integrating modern analytical tools--such as optimization models, simulation, data science, and artificial intelligence--the chapters illustrate how these methodologies can be effectively applied to enhance efficiency, adaptability, and sustainability in real-world systems. With its integrated and interdisciplinary perspective, this volume offers a holistic understanding of how optimization and intelligent technologies can transform complex decision-making environments. It serves as a valuable reference for researchers, practitioners, and policymakers interested in advancing analytical and optimization-based solutions to contemporary operational and managerial problems.