This volume presents a peer-reviewed selection of papers from the MISI'25 conference, held on July 9-10, 2025, in Safi, Morocco. It showcases recent advances at the intersection of mathematics and intelligent systems, offering solutions to real-world industrial, economic, and environmental challenges.

The volume highlights novel methodologies in optimization, data science, machine learning, numerical simulation, and control systems, applied across domains like healthcare, finance, energy, and education. It features case studies, algorithmic frameworks, comparative analyses, and data-driven modeling, supported by figures and tables for clarity and practical relevance. This book provides a comprehensive reference for researchers, practitioners, and graduate students seeking innovative approaches and applied strategies in mathematical and intelligent system applications.