This book provides a systematic introduction to the fundamental knowledge and the clinical applications of CT angiography derived fractional flow reserve (CT-FFR) technology, as well as its up-to-date advances. The first two chapters introduce basic anatomy and knowledge of coronary artery diseases. Then, the details of invasive assessment methods of coronary artery disease including coronary CT angiography are presented. In the following chapters, the clinical applications of CT-FFR in the diagnosis and prognosis of different cadiovascular diseases are discussed, highlighting atherosclerotic lesions, coronary revascularization, and congenital anomalies of the coronary artery. Accompanied with high quality illustrations, it is a valuable and comprehensive reference for radiologists and radiological technicians, postgraduates and all the related clinicians to understand the clinical applications of CT-FFR in details.